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Circadia · Vitamin A-Alternative Lotion · Authorized Retailer · Evening Use
EUK-134 + Pepha-ctive + Thymulen 4 + Chronocyclin — firms, energizes, and protects without retinol.
A rejuvenating Vitamin A-alternative evening lotion that delivers comprehensive anti-aging support — neutralizing reactive oxygen species, boosting mitochondrial energy, stimulating cell regeneration, and optimizing the skin\'s circadian renewal rhythms.
Vitamin A-Alternative Revitalizing Lotion
Circadia Revita-Cyte Complex Revitalizing Lotion is a professional-grade evening lotion that delivers comprehensive anti-aging regeneration through enzymatic antioxidant science, mitochondrial support, and immune-boosting peptides — making it an ideal alternative for those who cannot tolerate retinoids. EUK-134 (Ethylbisiminomethylguaiacol Manganese Chloride) is a synthetic mimic of both superoxide dismutase and catalase enzymes — scavenging superoxide radicals, eliminating hydrogen peroxide, transforming reactive oxygen species to water and oxygen, and reducing DNA and lipid free radical damage. Pepha-ctive (Microalgae/Algae Extract) protects and stimulates mitochondria by increasing ATP levels and improves skin radiance. Revitalin PF (purified mitochondrial and cytoplasmic fraction from yeast) stimulates cell respiratory activity, revitalizes skin metabolism, and strengthens self-protection mechanisms. Thymulen 4 (Acetyl Tetrapeptide-2) is a biomimetic of thymopoietin that boosts skin regeneration and reinforces cutaneous immune defenses for improved firmness and resilience. Exo-T (Vibrio Alginolyticus Ferment Filtrate) stimulates desquamation and transglutaminase expression for improved texture and tensile strength. Chronocyclin (Chronopeptide) enhances circadian gene expression, optimizes cell defenses and renewal activities, and supports Vitamin D transformation in sync with the skin\'s biological clock. Oat Beta Glucan activates the skin\'s natural repair system. Edelweiss Meristem Extract (Leontopodium Alpinum) provides additional antioxidant support.
Key Actives
Dual Enzyme Mimic
EUK-134
Ethylbisiminomethylguaiacol Manganese Chloride — a synthetic mimic of both superoxide dismutase (SOD) and catalase. Scavenges superoxide, eliminates hydrogen peroxide, transforms reactive oxygen species to harmless water and oxygen, and reduces free radical DNA and lipid damage.
Mitochondrial Energizer
Pepha-ctive
Microalgae/Algae Extract — protects and stimulates mitochondria by increasing ATP (cellular energy) production. Improves skin radiance and supports the metabolic cellular activity that declines with chronological aging.
Immune-Boosting Peptide
Thymulen 4 (Acetyl Tetrapeptide-2)
A biomimetic of thymopoietin — the thymus-derived hormone regulating immune function. Boosts skin regeneration and reinforces cutaneous immune defenses for improved firmness, resilience, and self-protection capacity.
Circadian Optimizer
Chronocyclin
Chronopeptide — enhances the expression of circadian (biological clock) genes, optimizes cellular defense and renewal activities, and supports Vitamin D transformation. Works in harmony with the skin\'s natural day-night repair rhythms.
Cellular Respirator
Revitalin PF
Purified mitochondrial and cytoplasmic fraction from yeast — stimulates cell respiratory activity and cell turnover, revitalizes skin metabolism, and strengthens the skin\'s self-protection mechanisms for enhanced resilience.
Texture Renewer
Exo-T
Vibrio Alginolyticus Ferment Filtrate — Polynesian atoll exopolysaccharide that stimulates desquamation, keratinocyte differentiation, and transglutaminase expression to regenerate skin and improve tensile strength, smoothness, and texture.
Benefits
EUK-134 provides unparalleled enzymatic ROS neutralization — protecting against the oxidative and UV-induced damage that accelerates skin aging, without the photosensitivity of retinoids.
Thymulen 4 reinforces skin immunity and regeneration. Revitalin PF stimulates cell turnover. Exo-T improves texture and tensile strength — collectively delivering firmer, smoother skin.
Pepha-ctive boosts mitochondrial ATP levels and Chronocyclin optimizes circadian gene expression — restoring the cellular energy and biological rhythm that dull, aging skin needs to renew.
Directions
Evening after cleanser and serum. No photosensitivity — no mandatory SPF increase required.
Cleanse & Apply Serum
Cleanse thoroughly in the evening and apply any targeted serums first. Revita-Cyte Complex is applied as the final moisturizing step in your evening routine.
Apply
Dispense 1–2 pumps onto fingertips and apply over the face and neck. Avoid contact with eyes. Unlike retinol, this formula does not cause photosensitivity — ideal for those seeking retinol-equivalent results without the restrictions.
Formulation
Key Actives
EUK-134 (Ethylbisiminomethylguaiacol Manganese Chloride) — SOD + catalase mimic; scavenges superoxide; eliminates hydrogen peroxide; transforms ROS to water/oxygen; reduces DNA and lipid damage.
Pepha-ctive (Algae Extract) — microalgae; stimulates mitochondria; increases ATP levels; improves skin radiance.
Revitalin PF (Glycoproteins) — purified mitochondrial and cytoplasmic fraction from yeast; stimulates cell respiratory activity; revitalizes skin metabolism.
Thymulen 4 (Acetyl Tetrapeptide-2) — thymopoietin biomimetic; boosts skin regeneration; reinforces cutaneous immune defenses; improves firmness.
Exo-T (Vibrio Alginolyticus Ferment Filtrate) — Polynesian exopolysaccharide; stimulates desquamation and transglutaminase; improves tensile strength, smoothness, and texture.
Chronocyclin (Glutamylamidoethyl Imidazole) — Chronopeptide; anti-aging; enhances circadian gene expression; optimizes cell defenses and renewal; Vitamin D transformation.
Oat Beta Glucan (Beta-Glucan) — immune stimulant; activates natural skin repair system.
Edelweiss Meristem (Leontopodium Alpinum Meristem Cell Culture) — antioxidant; anti-collagenase; anti-hyaluronidase.
Tocopherol (Vitamin E) — fat-soluble antioxidant; protects cellular membranes from free radicals.
Full Ingredient List
Aqua/Water, PPG-15 Stearyl Ether, Polysilicone-11, Glycerin, Squalane, Carbomer, Polysorbate 20, Butylene Glycol, Panthenol, Allantoin, Tocopheryl Acetate, Hydroxyethylpiperazine Ethane Sulfonic Acid, Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone, Leontopodium Alpinum Meristem Cell Culture, Caprylyl Glycol, 1,2-Hexanediol, Caprylic/Capric Triglyceride, Vibrio Alginolyticus Ferment Filtrate, Bisabolol, Phenoxyethanol, Laureth-12, Palmitoyl Tripeptide-38, Algae Extract, Acetyl Tetrapeptide-2, Glutamic Acid, Glycoproteins, Dextran, Dimethylmethoxy Chromanol, Ethylbisiminomethylguaiacol Manganese Chloride, Hydroxypropyl Cyclodextrin, Cananga Odorata Flower Extract, Ethylhexylglycerin, Sodium Benzoate, Potassium Sorbate, Avena Sativa Kernel Extract, Valine, Threonine, Xanthan Gum, Tetrasodium EDTA, Beta-Glucan, Glutamylamidoethyl Imidazole, Sodium Metabisulfite, Sorbic Acid, Linalool.
Specifications
| Brand | Circadia by Dr. Pugliese |
| Product Type | Vitamin A-alternative rejuvenating evening lotion |
| Skin Types | All Skin Types · Aging · Dull or Tired Skin · Post-SWiCH Support |
| Application | Evening after cleanser and serum; dispense 1–2 pumps; apply over face and neck; avoid eye contact |
| Key Actives | EUK-134, Pepha-ctive (Microalgae), Thymulen 4 (Acetyl Tetrapeptide-2), Revitalin PF, Oat Beta Glucan, Exo-T (Vibrio Alginolyticus), Chronocyclin, Edelweiss Meristem, Tocopherol |
| Contains | Linalool, Cananga Odorata (Ylang Ylang) Flower Extract — patch test recommended for fragrance sensitivities. |
| Retinol-Free | Yes — does not contain retinol or retinoids; no photosensitivity; no mandatory SPF increase required. |
| Sold By | Auréa Beauty — Authorized Circadia Retailer (myaurea.beauty) |
FAQ
Everything you need to know about Circadia Revita-Cyte Complex Revitalizing Lotion.
What is Circadia Revita-Cyte Complex?
A Vitamin A-alternative rejuvenating evening lotion for aging and dull skin. Key actives: EUK-134 (dual enzyme mimic), Pepha-ctive (mitochondrial ATP booster), Thymulen 4 (Acetyl Tetrapeptide-2), Chronocyclin (circadian peptide), Revitalin PF, Exo-T, and Oat Beta Glucan. Evening use only; retinol-free.
What is EUK-134?
EUK-134 is a synthetic mimic of both superoxide dismutase and catalase — two of the body\'s primary antioxidant enzymes. It scavenges superoxide radicals, eliminates hydrogen peroxide, converts reactive oxygen species to harmless water and oxygen, and protects against DNA and lipid damage in the skin.
What is Pepha-ctive?
Pepha-ctive is a microalgae extract that protects and stimulates mitochondria by increasing ATP (cellular energy) levels and improves skin radiance — supporting the metabolic cellular activity that declines with aging.
What is Thymulen 4?
Thymulen 4 (Acetyl Tetrapeptide-2) is a biomimetic of thymopoietin — a hormone from the thymus gland that regulates immune function. It boosts skin regeneration and reinforces cutaneous immune defenses for improved firmness and resilience.
Why is this called a Vitamin A alternative?
Revita-Cyte delivers comparable cell renewal, regeneration, and anti-aging support to retinol — through enzymatic antioxidants, mitochondrial activation, and immune-boosting peptides — without retinol\'s associated photosensitivity or irritation risk. Ideal for those who cannot tolerate retinoids.
What is Chronocyclin?
Chronocyclin (Glutamylamidoethyl Imidazole) is a Chronopeptide that enhances the expression of circadian genes, optimizes cell defense and renewal activities, and supports Vitamin D transformation — working in harmony with the skin\'s natural biological clock.
How do I use Revita-Cyte Complex?
Evening after cleanser and serum, dispense 1–2 pumps onto fingertips and apply over face and neck. Avoid eye contact. Unlike retinol products, no photosensitivity protocol is required.
Is Auréa Beauty an authorized Circadia retailer?
Yes. Auréa Beauty (myaurea.beauty) is an authorized Circadia professional skincare retailer. All products are 100% authentic and backed by the brand\'s quality guarantee.
Ideal For
For external use only. Avoid contact with eyes. Contains Linalool and Cananga Odorata Flower Extract — patch test recommended for fragrance sensitivities. If irritation occurs, discontinue use and consult a healthcare professional. Keep out of reach of children. Sold exclusively through authorized Circadia retailers. Auréa Beauty (myaurea.beauty) is an authorized Circadia professional skincare retailer.
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